Congratulations to the Gene Regulation group for their publication in Cell Systems
Congratulations to the Gene Regulation group for their publication in Cell Systems

Congratulations to the Gene Regulation group for their publication in Cell Systems

Dr Cameron Bracken, Professor Greg Goodall and colleagues published in this month's issue of Cell Systems  Vol.7 p77-91, July 25, 2018 "Combinatorial Targeting by MicroRNAs Co-ordinates Post-transcriptional Control of EMT". Image from their article is featured on the front cover of this issue.

This article represents a departure from the standard approaches as discussed by Davide Cora and Michele Caselle in the preview article of this issue "The Epithelial-Mesenchymal Transition, as Hacked by a microRNA Combinatorial Code". Bracken and colleagues used a combination of bioinformatics, high throughput sequencing, and functional validation to precisely describe the behavior of a circuit composed by a set of miRNAs acting combinatorially at molecular concentration close to cellular endogenous levels. Their focus is the human epithelial-mesenchymal transition (EMT), an important biological switch implicated both in development and diseases.

Image on the front cover of this issue shows the universe of breast cancer epithelial-mesenchymal plasticity. Showed that multiple miRNAs cooperate to drive a robust mesenchymal-to-epithelial transition within a cell line model of claudin-low breast cancer. The image shows a rotated representation of 1,102 TCGA breast cancer samples (hexbin density) and 72 breast cancer cell lines (circular markers) on a landscape defined by epithelial and mesenchymal molecular phenotypes. Hexbin colors reflect TCGA sample density (black, no samples; yellow, highest density).