Highlights included John Scott from University of Washington, Seattle, who is using super-resolution microscopy and proximity ligation techniques to visualise protein co-localisation in controlling spindle assembly. Frederic de Sauvage from Genentech, San Francisco, spoke of Wnt pathway function in intestinal stem-cells and is using several novel mouse models to investigate the role of intestinal stem cell niches in colorectal cancer. Xiaomeng Wang from Nanyang University, Singapore, spoke of a novel modulator of TGF-beta signalling, LRG1, and its role in keratinocytes and skin carcinogenesis. Ivan Dikic of Goethe University, Frankfurt, talked about the crosstalk between phosphorylation and ubiquitination in regulating protein function. Richard Marais of Cancer Research UK, Manchester, spoke of novel xenograft mouse models of melanoma, and the use of patient samples to predict personalised drug treatment regime outcomes. KJ Patel of Cambridge University gave an entertaining presentation on the role of alcohol and aldehydes in inducing DNA damage, leading to cancer.